| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
pH-Responsive Catechol-Fe3+ Cross-Linked Polymer Micelles for Tumor Therapy |
| 초록 |
Polymer micelles (PMs) have been extensively explored as intravenous nanocarriers. However, they have poor stability in systemic blood circulation, which leads to micelle dissociation and premature drug release before reaching the target cell. To overcome these problems, core or shell cross-linking techniques have been introduced. Recent reports suggested that coordination bond between Fe3+ and catechol ligand is as strong as covalent bonds and has pH-sensitive association/dissociation property. As pH increases from 5 to 12, the complex of catechol-Fe3+ changes from mono-complex to tris-complex. We have developed pH-tunable polymer micelles (CLPMs) of PEG-b-poly(L-3,4-dihydroxy phenylalanine) (PEG-PDOPA) copolymer, in which the PDOPA core was cross-linked by Fe3+. This CLPM can hold the drug at physiological pH and can release the drug in acidic condition. |
| 저자 |
황규하, 민경현, 이홍재, 구안나, 정서영, 이상천
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| 소속 |
경희대 |
| 키워드 |
pH-responsive; catecholate polymer; metal coordination; reversible cross-links
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| E-Mail |
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