| 초록 |
Recently, the injection laryngoplasty techniques for managing of glottal insufficiency have gained popularity because of its initial low cost, minimal invasiveness, and low morbidity as compared to surgical repair method. A number of injectable substances have been adapted in the clinical practice, however, relatively short-term volume stability (by migration and resorption), inflammation, granuloma formation, and decreased vocal fold vibration are considered as limitations for practical use. In this study, we prepared growth factor (bFGF or HGF)-immobilized PCL microspheres as an injectable bioactive bulking agent which can provide a bulking effect and stimulate smooth muscle in vocal fold for effective treatment of glottal insufficiency. The growth factor release and adhesion/proliferation of vocal fold fibroblasts on the growth factor-immobilized microsphere were investigated [This work was supported by the National Research Foundation of Korea (NRF-2014R1A2A2A04003979)]. |
