| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 |
19권 1호 |
| 발표분야 |
고분자_포스터 |
| 제목 |
Microgrooved Titanium with Dual Growth Factor-Releasing Nanoparticles for Synergistic Osteogenic Activity |
| 초록 |
In this work, we demonstrate that controlled dual release of bone morphogenic protein-2 (BMP-2) and insulin-like growth factor-1 (IGF-1) by catechol-functionalized adhesive polymer nanoparticles on microgrooved titanium (Ti) surface enhances in vitro osteoblastic differentiation of human mesenchymal stem cells (MSCs). The nanoparticles were immobilized both on the groove bottom surface and the ridge top surface. A fluorescence microscope visualized that BMP-2 and IGF-1 of positive charges were efficiently loaded onto the nanoparticle-immobilized Ti surfaces. We confirmed the enhanced osteoblastic differentiation of MSCs by presenting the expression results of major osteoblast marker genes and proteins. The proposed combined surface of microgrooves and growth factor-releasing nanoparticles can be used as a strong osteogenic promoter on various biomaterial surfaces. |
| 저자 |
이석원1, 이홍재2, 이재원2, 제갈준호2, 김경희1, 강종호3, 이명현3, 이상천2
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| 소속 |
1강동경희대, 2경희대, 3한국세라믹기술원 |
| 키워드 |
Microgroove; Nanoparticle; dual growth factor; osteoblastic; catechol
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| E-Mail |
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