| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 봄 (04/11 ~ 04/12, 연세대학교) |
| 권호 | 28권 1호, p.344 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Reconstruction of Blood Vessel for Tissue Engineering from Elastic Biodegradable Polymers |
| 초록 | A tissue engineering approach has been developed to produce arbitrary lengths of vascular graft material from smooth muscle and endothelial cells that were derived from a biopsy of vascular tissue. Recently, many studies have been reported that mechanical stimuli enhanced the development and function of engineered tissues. So it is likely to be necessary that the development of elastic scaffolds can maintain their mechanical integrity and deliver the mechanical signals to adherent cells during mechanical strain application. In this study, Poly(L-lactide-co-caprolactone)(PLCL) copolymer were synthesized. There polymer were characterized by 1H-NMR, GPC, DSC and so on. Vascular grafts(I.D. 0.5cm) were fabricatred from novel PLCL and sequentially seeded with dog vascular smooth muscle cells(SMCs) and endothelial cells. After 5 days static culture, the grafts were grown in vitro in a pulse duplicator system(bioreactor) for 7 and 28 days. Analyses of tissue included histology, protein assay, SEM and western of engineered vessels. This study demonstrates the feasibility of tissue engineering of viable, surgically implantable small caliber vascular grafts and the important effect of a biomimetic in vitro environment on tissue maturation and extracellular matrix formation. |
| 저자 | 정성인 ;김수현;김병수;김동익;이수홍;최지아;조승우;김영하 |
| 소속 | 한국과학기술(연) |
| 키워드 | Tissue Engineering; Blood Vessel; Elastic Biodegrable polymer; PLCL |
