| 초록 |
Alginate is a natural polysaccharide forming hydrogel network by ionic cross-links in the presence of divalent cations. It has been therefore widely used in various fields. In this work, calcium ion-sensitive hydrogel was fabricated with norbornene-functionalized poly(ethylene glycol) (PEG) and alginate via thiol-norbornene photo-click reaction. Hydrogel property was modulated by controlling alginate-norbornene contents in blend hydrogels. In addition, the swelling ratio of alginate-PEG hydrogel was reversibly modulated with calcium ions and sequestrant (i.e., EDTA). Multi-layer hydrogel which was formed by pure PEG-norbornene hydrogel layer and alginate-norbornene layer showed reversible bending motion in calcium chloride solution. These results suggest that thiol-norbornene PEG/alginate hybrid hydrogel would be potentially used as a stimuli-responsive material in a wide variety of applications. |
