| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터) |
| 권호 |
42권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Enzyme-Mediated Oxidative Stress Enhancing Mineralized Nanoparticles. |
| 초록 |
Some of reactive oxygen species (ROS) are highly toxic and act as key therapeutic molecules for cancer treatment. It is known that cancer cells are more vulnerable than normal cells to the oxidative stress. Thus, there have been many attempts to modulate the ROS level to kill the cancer cells. In particular, the Fenton reaction that amplifies the oxidative stress by generating hydroxyl radicals has been recognized as one of the powerful routes for effective cancer therapy. The purpose of this work is to develop a superoxide dismutase (SOD)-loaded mineralized nanoparticle that can intracellularly enhance the level of hydrogen peroxide (H2O2) and can trigger the subsequent conversion of H2O2 into highly toxic apoptosis-inducing hydroxyl radicals. This mineralized nanoparticle that enables enzyme-mediated oxidative stress amplification may find broad applications in treatment of various cancers. |
| 저자 |
김혜정, 이홍재, 이상천
|
| 소속 |
경희대 |
| 키워드 |
Superoxide Dismutase(SOD); Reactive Oxygen Species(ROS); Nanoparticle; Fenton like reaction; Cancer treatment.
|
| E-Mail |
|
