| 학회 |
한국재료학회 |
| 학술대회 |
2016년 가을 (11/16 ~ 11/18, 경주 현대호텔) |
| 권호 |
22권 2호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
Amphiphilic antiviral delivery nanoplatform consisting of cell-targeting phenylboronic acid functional groups for Influenza virus therapy |
| 초록 |
Influenza, one of the most contagious diseases, has caused seasonal epidemics and pandemics being a consistent concern for global health. Despite laudable advances in antiviral agents and drugs, the vast majority of them have shown limited efficacy due to non-specificity and low viability in physiological or endosomal environment, especially in the case of intracellular drug. A nano platform, consisting of phenylboronic acid (PBA) pendant group polymer which has sialic acid-targeting property, gained greater access to the intracellular space transporting antivirals within the host cell. Amphiphilic copolymers made of pPhe-b-mPEG-PBA formed polymersomes which encapsulated hydrophilic antiviral agents in the core and hydrophobic drugs in the exterior layer. Combination of antiviral drug delivery using amphiphilic nanocarrier and cell-targeting functional group gives a better chance to improve transfection and intracellular distribution efficiency of therapeutic substances. |
| 저자 |
천해진1, 김현욱1, 나운성2, 염민주2, 임종우1, 윤다연1, 김지혜1, 박근선1, 함승주1
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| 소속 |
1연세대, 2고려대 |
| 키워드 |
<P>phenylboronic acid; antiviral; nanoparticle; drug delivery; influenza</P>
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| E-Mail |
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