| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Sol-Gel-Sol Transition of MPEG-PCL Diblock Copolymers |
| 초록 | Polymers that response to external stimuli have been investigated for the controlled-release drug carriers. Especially, PEG-based diblock and triblock polyester copolymers, stimulating to temperature were studied as injectable drug delivery system due to their nontoxicity, biocompatibility and biodegradability. We synthesized the diblock copolymers consisting of methoxy polyethylene glycol and ε-caprolactone by ring opening polymerization via activated monomer mechanism. The concentrated solution of synthesized diblock copolymer represented a sol to gel phase transition as the temperature increased from room temperature to body temperature. Above 45 oC, these block copolymers again displayed a sol phase. To confirm the gel formation at body temperature, we observed the formation of gel in the mice body after injection of 20 wt% aqueous solution of each block copolymer. After 1 month, we investigated the gelation without dispersion in mice. The results obtained in this study confirmed the feasibility as biomaterials of injectable implantation for controlled release of drug and protein delivery. Acknowledgement : This work was supported by KMOCIE (N11-A08-1402-05-1-3) |
| 저자 | 김문석1, 현훈1, 강길선2, 이해방1 |
| 소속 | 1한국화학(연), 2전북대 |
| 키워드 | MPEG-PCL; sol-gel-sol |
