| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
정밀화학_포스터 |
| 제목 |
Stiffness analysis of synthesized protease degradable hydrogel based on hyaluronic acid |
| 초록 |
In this presentation, we proposed a method for preparing hydrogels degradable by alpha-chymotrypsin. Protease initiated degradation was revealed by the stiffness analysis before and after treating protease. The protease degradable hydrogel is composed of acrylated hyaluronic acid crosslinked by a peptide crosslinker containing a proteolytic degradation site. Proteolytic degradation site is a peptide that sequence ‘CYKC’ is cleavable by alpha-chymotrypsin treatment. Two thiol groups from terminal cysteines can be crosslinked with acrylated hyaluronic acid by thiol-ene click reaction. The protease degradation of hydrogel was monitored by measuring stiffness changes. We envision that these protease degradable hydrogels are useful for tissue engineering and drug delivery. |
| 저자 |
박경은1, 전영은1, 김성수2, 신동식1
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| 소속 |
1숙명여자대, 2강원대 |
| 키워드 |
hydrogels; alpha-chymotrypsin; hyaluronic acid; stiffness
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| E-Mail |
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