| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
생물공학_포스터 |
| 제목 |
Sericin with low doses of gamma irradiation reduced inflammatory response in skin cells |
| 초록 |
Sericin serves as additive in cosmetics and food industries. It shows that skin cells have brought about the improvement of secicin-based biomaterials for skin repair application. In this study, we tried to improve the commercial application possibility by constructing optimal gamma irradiation doses for sericin. Low dose of gamma irradiated sericin exhibited more potent macrophage polarization to the M2 phenotype in cells and reduced anti-inflammatory response, copared with non-irradiated sericin. Furthermore, low dose of gamma irradiated sericin treating cells dramatically suppressed cytokine complex induced cell death and pro-inflammatory factors. From these findings, the gamma irradiation method of less than 10 kGy is considered to be an effective method for the practical use of sericin and plays an important role in the use of high functional biotechnology products by increasing anti-inflammatory activity. |
| 저자 |
최원영1, 박준수1, 김소현1, 이세인1, 이하나1, 권미진2, 이계원1, 조영호1
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| 소속 |
1건양대, 2(주)PSA |
| 키워드 |
Sericin; gamma irradiation; anti-inflammatory activity; cosmetics; cytokines
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| E-Mail |
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