| 초록 |
Many studies have been reported on light-stimulated drug delivery for cancer treatment. However, the photo-stimulated drug delivery present low medicinal efficacy for cancer treatment and unintended side effects. In this study, we developed light-stimulated drug vehicle (LDV) activates in hypoxic tumor microenvironment and light exposure. The LDV contained an anti-cancer drug and organized by reactive oxygen species (ROS)-mediated degradation of photosensitizer conjuagated in polysaccharides. In hypoxic condition, ROS was produced by the electron abundant polysaccharide chains. The ROS generated by LDV facilitated drug release at hypoxic condition in laser irradiation. An anti-cancer drug loaded LDV showed toxicity in cancer cell line under hypoxia than that normal oxygen condition. In vivo and ex vivo experiments demonstrated that LDV accumulated in the tumor site. Thus, this study could be efficient methods for cancer therapeutics and hypoxic conditional diseases. |
