| 초록 |
Anti-inflammatory drugs have been applied to improve the function of stent, so called ‘drug-eluting stents’. Many researchers reported that the reduction in neointimal hyperplasia and restenosis in stent could be accomplished by stent-based delivery of anti-immune drugs, such as sirolimus, paclitaxel and so on. However, the application of these drugs still has some major concerns. In this study, we hypothesized that the combinational treatment of vinpocetine and AcSDKP inhibits the inflammatory response of endothelial cells and smooth muscle cells (SMC) without the endothelial toxicity. Additionally, it was examined the effect of this combination on macrophage infiltration and SMC proliferation. As a result, it was observed that the combinational treatment of vinpocetine and AcSDKP decreased pro-inflammatory cytokines and macrophage infiltration, and also, it could reduce the SMC proliferation. |
