| 초록 |
In this study, to improve the efficacy and the bioavailability of paclitaxel, it is very important to investigate the interaction between modified drugs and Serum Proteins. And fluorescent analogues of drugs, with a high quantum yield, are widely used as important tools in studies of the elucidation of structures and the mechanisms of drug binding to proteins and nucleic acids etc. To gain a better understanding of the mechanism of drug action of paclitaxel as well as the environment of the paclitaxel-binding site, fluorescent 1-pyrenbutyrate will be incorporated in the carbon 2’ of a paclitaxel prodrug (PP7). These synthesized compounds will be subsequently characterized by fluorescence spectrometry etc. It could thus be used for the in-vivo study of bioactivities and the efficacy of paclitaxel. |
