| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
방사광을 이용한 고분자 나노소재 연구 |
| 제목 |
Structural change of i-Motif DNA at various pH conditions in solution |
| 초록 |
Structural change of i-motif DNA at various pH conditions in solution, which is proton-sensitive DNA molecule based on i-motif conformation, was investigated by SAXS (Small Angle X-ray Scattering) technique. Atomic models of i-motif DNA were applied for understanding correlation of solution structure of the DNA at various pH values. Partially unfolded theoretical model is similar to conformation of mild acidic condition, rather than the fully folded i-motif atomic model. The structural model for i-motif DNA at neutral condition exhibited a distorted M-shaped form that significantly deviated from the relatively compact globular form of i-motif DNA at mild acidic condition. The i-motif DNA in basic solution apparently adopted a fully random coil conformation. Collectively, these facts mean that i-motif DNA molecule is structurally dynamic over a wide pH range, adopting multiple conformations ranging from the folded i-motif structure to a random coil conformation. |
| 저자 |
노예철1, 진경식2, 신수련3, 안병철1, 진상우1, 이택준1, 박삼대1, 김진철1, 김동민1, 정정운1, 권원상1, 김경태1, 김미희1, 고용기1, 김선정3, 이문호1
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| 소속 |
1포항공과대, 2포항가속기(연), 3한양대 |
| 키워드 |
SAXS; solution SAXS; i-motif DNA; pH
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| E-Mail |
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