| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 |
20권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Decellularized Nanofibrous Scaffolds for Bone Tissue Engineering |
| 초록 |
Scaffolds serve a key role in improving tissue regeneration by stem cells. Here, we report a decellularized tendon-derived scaffold with nanofibrous structures, which can enhance osteogenic differentiation and bone formation of human adipose-derived stem cells (hADSCs). Decellularized tendon scaffolds induce highly enhanced alignment and extension of hADSCs, leading to enhanced osteogenic differentiation of hADSCs in vitro. Transplantation of hADSCs using tendon scaffolds significantly promoted bone formation in a critical-sized calvarial bone defect model. Stacking the scaffolds seeded with hADSCs and human endothelial progenitor cells (hEPCs) further enhanced in vivo bone regeneration. In this study, we suggest a biomimetic tendon scaffold providing an efficient biomaterial platform for bone tissue engineering. This study was supported by a grant (2009-0083522) from Translational Research Center for Protein Function Control (TRCP) funded by the MSIP, Republic of Korea. |
| 저자 |
이종승1, 고은경1, Kyle Alberti2, 양기석1, 신지수1, 양희석3, Qizobing Xu2, 조승우1
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| 소속 |
1연세대, 2Tufts Univ., 3단국대 |
| 키워드 |
Decellularized tendon-derived scaffold; Human adipose-derived stem cell; Bone tissue engineering
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| E-Mail |
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