| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Synthesis and Characterization of N-acyl Glycol Chitosans as a New Thermogelling Polymer for Biomedical Applications |
| 초록 |
A series of thermo-sensitive N-acyl glycol chitosans were synthesized by a simple one-step N-acylation of glycol chitosan with acetic anhydrides and hexanoic anhydrides. N-acyl glycol chitosans with different molecular weights of hydrophobic groups and degree of acylation (DA) were synthesized to improve their hydrophobicity and stability. The chemical structures and viscoelastic properties of N-acylation of glycol chitosans were characterized by FT-IR, 1H-NMR and rheometer. The influence of molecular weight of hydrophobic group and degree of acetylation was studied by tube inverting method on the thermo-sensitive sol-gel transition properties of N-acyl glycol chitosans. Biocompatible and thermo-sensitive N-acyl glycol chitosans hold great promise serving as new in-situ thermogelling platforms for various biomedical applications. |
| 저자 |
문지연1, 홍윤정1, 김세희2, 심혜은2, 권보선3
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| 소속 |
1(주)위노바, 2우리들휴브레인(주), 3(주)위노바 / 우리들휴브레인(주) |
| 키워드 |
Thermogelling polymer; Glycol chitosan; sol-gel transition; biomedical application
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| E-Mail |
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