| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
The Inflammatory Responses on Poly(lactic-co-glycolic acid) Scaffold Compounded Hesperidin |
| 초록 |
Hesperidin (Hes) as a type of flavonoid is rich in citrus rind and has effects on anti-aging and anti-cancer by affecting blood pressure, antioxidant, anti-inflammatory. The goal of this study is to demonstrate the relationship between Hes and inflammatory in vitro and in vivo. The three-dimensional PLGA scaffolds mixed with Hes 3, 5, and 10% were produced by casting/salt extraction method and confirmed cell attachment and proliferation by the SEM and WST assay anti-inflammatory and antioxidant effects by RT-PCR, and FACS in vitro. To characterize in vivo inflammatory responses surrounding the implants, histological examinations was performed at 1 or 4 weeks after implantation. 5% Hes /PLGA scaffold demonstrated better than other wt% Hes /PLGA scaffolds. Thus, Hes has a possibility as a biomaterial for tissue engineering. This research was supported by NRF-2012M3A9C6050204 and the Brain Korea 21 PLUS Project, NRF. |
| 저자 |
양재원, 장나금, 고현아, 송정은, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
PLGA; Hesperidin; Scaffold; inflammatory .
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| E-Mail |
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