| 초록 |
Over the decades, ultrasound-assisted drug delivery system has been extensively studied as a strategy for improvement of drug accumulation on tumor. Of the strategies, mild hyperthermia-involved liposomal drug delivery and has been intensively studied for thermal-triggered release of drug. However, several results about unexpected thermal damage to the vessels and the tissues that may occur side effect was reported. Herein, we have developed non-thermal acoustic treatment as an alternative of mild hyperthermia treatment to reduce thermal side effect of mild hyperthermia-involved liposomal drug delivery system and we extensively evaluated the effect on vessel permeability and drug accumulation into tumor tissues using near infra-red fluorescent imaging with Cy5.5-labeled liposomes. As a results, non-thermal acoustic treatment successfully improved tissue penetration of liposomes and drug as much as mild hyperthermia treatment without thermal damage. |
