| 초록 |
Glutathione (GSH, γ-glutamyl-cysteinyl-glycine) is the most abundant non-protein thiol in eukaryotic cells. This glutathione plays an essential role in cancer cells and, it is particularly relevant in regulating carcinogenic mechanisms, sensitivity against cytotoxic drugs and some cytokines, DNA synthesis, and cell proliferation and death. In this work, we report GSH-depleting for chemodynamic therapy of cancer. The nanocomposite is composed of GSH-consuming chemosensitizer MnO2, and hydrophilic shell carboxymethyl dextran. The in vitro cells experiment exemplified that the nanocomposites can deplete the intracellular GSH level by reducing MnO2 to Mn2+, which generates ROS, and the nanocomposites that produce singlet oxygen. The chemodynamic activity of this nanocomposite occurs in the apoptosis of the cancer cells, implying their high potential as anticancer therapeutics. |
