| 학회 |
한국화학공학회 |
| 학술대회 |
2013년 봄 (04/24 ~ 04/26, 광주 김대중컨벤션센터) |
| 권호 |
19권 1호, p.173 |
| 발표분야 |
공정시스템 |
| 제목 |
Modeling and Simulation of Polymorphic Transformation of L-Glutamic Acid and Optimization Strategy for Cooling Crystallization of α-Form Crystals |
| 초록 |
L-glutamic acid can be crystallized as metastable α-form and stable β-form crystal. The α-form is desired because of its prismatic shape. Production of α-form of L-glutamic acid by cooling crystallization is not well-defined and α-form solid is commercially not available. In this study, an optimal cooling strategy to selectively produce large and narrowly distributed α-crystals is found by modeling and optimizing the crystallization and polymorphic transformation of L-glutamic acid. The optimal temperature profile is found to be cooling-heating-cooling concept where short nucleation period is followed by growth period in metastable zone. The obtained α-form of L-glutamic acid by optimal strategy had improved mean size, distribution, and purity compared to constant cooling. |
| 저자 |
염승종, 양대륙
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| 소속 |
고려대 |
| 키워드 |
Cooling Crystallization; Population Balance; Polymorphic Transformation; L-Glutamic Acid; Optimization
|
| E-Mail |
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| 원문파일 |
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