| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
생물공학_포스터 |
| 제목 |
Enhanced Expression of Growth Factors and Gap Junction Protein by Reduced Graphene Oxide for Myocardial Infarction |
| 초록 |
Myocardial infarction (MI) is one of the major cardiovascular diseases which causes death around the world. The loss of cardiac cells, which express gap junction proteins, and cardiac fibrosis in myocardial infarction lead to arrhythmia. Mesenchymal stem cell (MSC) implantation has been emerging strategy for cardiac repair after MI. Herein, we report reduced graphene oxide (RGO) which shows high affinity to extracellular matrix (ECM) proteins and high electrical conductivity. We hypothesized that incorporated RGO into MSC spheroid would improve the therapeutic efficacy for MI via the secretion of reparative paracrine factors and the upregulation of gap junction proteins. RGO could not only promote paracrine factors secretion and gap junction crosstalk, but also could be fabricated into implantable thin shape. RGO flakes could promote important factors of MSC spheroid for cardiac repair. Therefore, MSC-RGO hybrid spheroids can be used therapy for MI. |
| 저자 |
이주로1, 김병수1, 박주연1, 유승미1, 김용숙2
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| 소속 |
1서울대, 2전남대 |
| 키워드 |
Myocardial infarction; Reduced graphene oxide; Growth factor; Gap junction
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| E-Mail |
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