| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Fabrication and Characterization of Composite Nanoparticles Growth Factor Delivery. |
| 초록 |
The chitosan stabilized F-68/PVA/heparin composite nanoparticles is designed and characterized for growth factor delivery. F-68 (poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) triblock copolymer) and heparin forms by hydrogen bonding in water, and this mixture formed complex nanoparticles by electrostatic interaction with positively charged chitosan. TGF-ß2, a model growth factor, was loaded before the formation of complex nanoparticles by chitosan. FE-SEM was used to observe the formation of chitosan stabilized F-68/PVA/heparin nanoparticles complex and ELS was used to observe the size distribution and zeta-potential. The amount of released TGF-ß2 was determined by ELISA. TGF-ß2 was loaded into nanoparticles complex, and a sustained release was observed maintaining its bioactivity. These indicate that the nanoparticles complex in this study can be utilized as a sustained delivery system for growth factor. |
| 저자 |
오근상1, 이희훈1, 이진호1, 임군일2, 육순홍1
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| 소속 |
1한남대, 2동국대 |
| 키워드 |
Chitosan; Growth factor; Nanoparticles
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| E-Mail |
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