| 초록 |
Spontaneous, highly ordered large-scale fibronectin networks driven by electrostatic polymer patterns are fabricated, and these precisely controlled protein connections are demonstrated. It is examined whether this scheme, universal to various fibrillar extracellular matrix proteins beyond fibronectin, collagen, and laminin, can be self-organized. These data reveal a novel bottom-up method to form anisotropic, free-standing protein networks to be used as flexible, transferrable substrates for cardiac and neuronal tissue engineering. We further demonstrated applications of these networks to template the formation of ECM composite fibers and cell patches, so-called “cell sticker”. We will present our recent application, using “cell sticker”, applying self-healing patches for dermatological, and organ-specific application. |
