| 초록 |
Tumor microenvironments play critical roles in cancer cell behavior including cancer progression and drug resistance. Recently, various bioinspired hydrogels have been utilized as engineered tumor models that recapitulate the multiple parameters in the native tumor microenvironments. Herein, we present gelatin and poly (ethylene glycol)-based interpenetrating network (IPN) hydrogels as engineered 3D lung carcinoma models. The hydrogels were formed via horseradish peroxidase-mediated dual cross-linking reactions, exhibiting controllable physicochemical properties. We encapsulated human lung carcinoma cells into hydrogels to investigate the drug response of the cancer cells against gefitinib (a clinically used anti-cancer agent) in the 3D microenvironment. In conclusion, our hydrogels are considered as a promising platform to study basic cancer biology and screening of therapeutic agents for better clinical outcomes. |
