| 학회 |
한국화학공학회 |
| 학술대회 |
2012년 봄 (04/25 ~ 04/27, 제주 ICC) |
| 권호 |
18권 1호, p.431 |
| 발표분야 |
생물화공 |
| 제목 |
Flavone Reduces the Production of Virulence Factors in Staphylococcus aureus |
| 초록 |
Staphylococcus aureus is a leading cause of nosocomial infections due to its resistance to diverse antibiotics. This bacterium produces a large number of extracellular virulence factors that are closely associated with specific diseases. In this study, twelve plant flavonoids were investigated to identify a novel anti-virulence compound against S. aureus. Flavone, a backbone compound of flavonoids, at subinhibitory concentration markedly reduced the production of staphyloxanthin and α-hemolysin. This staphyloxanthin reduction rendered the S. aureus cells 100 times more vulnerable to hydrogen peroxide in the presence of flavone. In addition, flavone significantly decreased the hemolysis of human red blood by S. aureus and the transcriptional level of α-hemolysin gene hla and a global regulator gene sae in S. aureus cells. This finding supported the potential of flavone as a potential as an antivirulence agent and provides a starting point in the design of potent drugs against antibiotic-resistant S. aureus. |
| 저자 |
박주현1, 이진형2, 조무환1, 이진태2
|
| 소속 |
1School of Chemical Engineering, 2Yeungnam Univ. |
| 키워드 |
antivirulence compound; hemolysis; Staphylococcus aureus; staphyloxanthin
|
| E-Mail |
|
| 원문파일 |
초록 보기 |
