| 학회 | 한국공업화학회 |
| 학술대회 | 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 23권 2호 |
| 발표분야 | 포스터_생체재료 |
| 제목 | Endosome and lysosome evading ROS generable light reactive micelle for cancer treatment |
| 초록 | Over the years, the nanotechnology with micelles has been proven their potential to diagnosis and alleviate the cancers. Furthermore, reactive oxygen species (ROS) which is known for their ability to regulate biological functions. In contrast, their limitations such as drug release profile and severe side effects have been become a challenge to use. Additionally, evading the endosome and lysosome that are kind of the biological barricades would be significant approach to be a suitable treatment. In order to resolve the aforementioned challenges, we constructed drug and photosensitizer (PS) loaded ROS generable light reactive micelle (RLRM). Under the specific wavelength, PS generate ROS. Consequently, ROS make RLRM to release drugs, and the layer of endosome and lysosome become weaken in the tumor. In vivo test, under the irradiation, RLRM showed tend to reduce the tumor size. In summary, RLRM successfully released drug and PS, thus it could be led the field of cancer treatment. |
| 저자 | 진민영, 김기홍, 이충성, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | reactive oxygen species; endosome; lysosome; photosensitizer; micelle |
