| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
In situ RGD conjugated-Tetronic based hydrogel as an injectable bio-mimetic scaffoldfor tissue engineering applications |
| 초록 |
Recently, the development of ideal biomaterials for tissue engineering has been focused on the design of bio-mimetic materials that can mimic the natural environments in the extracellular matrix. Arg-Gly-Asp (RGD) sequence, the signaling domain derived from fibronectin and laminin, has been commonly used for preparing the bio-mimetic scaffolds. In this study, in situ RGD-conjugated Tetronic-tyramine (Tet-TA) hydrogels was prepared via enzymatic reaction. Tet-TA hydrogel was rapidly formed and GRGDGGGGGY peptide was conjugated simultaneously in the presence of horseradish peroxidase and H2O2. In vitro cell study demonstrated that in situ conjugated RGD peptides with glycine and tyrosine residues facilitate the enhanced attachment of a variety of cells. Thus, in situ conjugation of the RGD peptide to injectable hydrogel via enzymatic reaction may be an efficient tool to prepare injectable bio-mimetic hydrogels for tissue engineering applications. |
| 저자 |
박경민1, 전인동2, 정윤기1, 신흥수2, 박기동1
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| 소속 |
1아주대, 2한양대 |
| 키워드 |
in situ forming hydrogel; RGD; Tetronic; Tissue engineering
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| E-Mail |
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