| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 가을 (10/10 ~ 10/11, 부경대학교) |
| 권호 | 28권 2호, p.85 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Effect of lactide/glcolide monomers on release behaviors of gentamicin sulfate-loaded PLGA devices for antibiotic local delivery system |
| 초록 | Gentamicin sulfate (GS), a highly water soluble antibiotic of the aminoglycoside group, is widely used for the treatment of serious infections such as osteomyelitis and the prevention of secondary infections after orthopedic surgery. GS/PLGA wafers and powders were prepared by direct compression method and melt extrusion method, respectively. For the desirable drug release patterns and removal of lag periods which frequently might show in the PLGA devices, lactide/glycolide monomers were introduced since they have non-toxic and biodegradable property in in vitro/in vivo. We have investigated the effects of sizes and additives. In vitro study was performed in pH 7.4 phosphate buffered saline (PBS) at 37℃. Drug contents and release amounts of GS were analyzed by high performed liquid chromatography (HPLC). Morphological evaluation of the devices was accomplished by scanning electron microscope (SEM). Moreover, differential scanning calorimetry (DSC) and gel permeation chromatography (GPC) were used for their characterization. From the result of in vitro release test, we could obtain the desirable drug release patterns without lag periods from the prepared GS/PLGA wafers and powders containing lactide/glycolide monomers. Acknowledgment : This work was supported by KMOHW and KOSEF (R01-2001-00431) |
| 저자 | 유제영1, 김종민1, 정제교2, 김문석3, 조선행3, 강길선1, 이해방3 |
| 소속 | 1전북대, 2삼천당제약 중앙(연), 3한국화학(연) |
| 키워드 | PLGA; Gentamacin sulfate; Glycolide monomer; Lactide monomer |
