| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 가을 (10/10 ~ 10/11, 부경대학교) |
| 권호 | 28권 2호, p.247 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Development of desirable dexamethasone-loaded PLGA wafers containing glycolide monomer for the sustained release |
| 초록 | The aim of this study is to develop poly(D,L-lactide-co-glycolide) (PLGA) wafers containing glycolide monomer for the continuous delivery of dexamethasone for over two weeks in an effort to suppress the chronic inflammatory reactions like otitis media. The conventional direct compression method was applied to fabricate the wafers. Glycolide monomer was incorporated into PLGA matrix to overcome the lag period and to influence the release of drug. The in vitro release studies were performed in phosphate buffered saline (pH 7.4) at the constant temperature (37℃) under sink condition. From the result of in vitro release test, we could induce the desirable drug release patterns by means of adequate amount of glycolide monomer. In conclusion, glycolide monomers could induce the remarkable drug release and control of lag period of PLGA devices. Further investigation is being carried out to confirm the effect of dexamethasone-loaded PLGA wafers containing glycolide monomer in in vivo. Acknowledgment : This work was supported by KMOHW and KOSEF (R01-2001-00431) |
| 저자 | 김종민1, 유제영1, 정제교2, 김문석3, 조선행3, 강길선1, 이해방3 |
| 소속 | 1전북대, 2삼천당제약 중앙(연), 3한국화학(연) |
| 키워드 | Dexamethasone; Glycolide monomer; Wafer |
