| 초록 |
Postoperative tissue adhesions are the development of abnormal fibrous bands between tissues and organs in response to trauma and infection. It is well known that the tissue adhesions entail severe pain, functional obstruction of organs, and sometimes difficult re-operative surgery. In our previous study, we discovered that the non-crosslinked alginate film can be a good candidate as a tissue adhesion barrier owing to its muco-adhesive property at the dried state and the following lubricant property on dissolution in the body. In this study, we homogeneously applied a non-crosslinked alginate powder onto the injured peritoneal defect site by spraying, and its role to prevent tissue adhesion during the wound healing and potential for clinical applications as a tissue adhesion barrier were investigated through the comparison with other alginate-based barriers (film-, solution-, and gel-type) and a commercialized tissue adhesion barrier, InterceedTM using a rat model. |
