| 학회 |
한국화학공학회 |
| 학술대회 |
2020년 가을 (10/14 ~ 10/16, e-컨퍼런스) |
| 권호 |
26권 1호, p.977 |
| 발표분야 |
나노기술과 분자진단 심포지엄(생물화공부문위원회) |
| 제목 |
Peptide-decorated nanoparticlesfor cellular targeting |
| 초록 |
Exploiting the molecular recognition of receptors presented on the cell surface have extensively opened up diagnostic and therapeutic application of nanoparticles. A targeted nanoparticle is required to report confirmation of specific interactions and ultimate fate in physiological environment for further verification. We have demonstrated tracking of homing peptide-decorated biodegradable silicon nanoparticles through intrinsic photoluminescence during the course of cellular targeting and uptake. The photoluminescence emission lifetime is on the order of microseconds, which is significantly longer than tissue autofluorescence, thus allows clear discrimination of the nanoparticles for the noisy cellular background. Utilizing the time-resolved analysis of luminescent emission, we further investigated the multivalent strategy of nanoparticles for enhanced cell targeting. The result presents a promising potential of the biodegradable silicon nanoparticles toward advanced cell targeting systems that simultaneously enable tracking the intracellular behavier and the tissue microenvironment monitoring. |
| 저자 |
주진명 |
| 소속 |
울산과학기술원 |
| 키워드 |
nanoparticle; peptide; cellular trafficking; targeting; bioimaging
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| E-Mail |
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| 원문파일 |
초록 보기 |
