| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Hyaluronic Acid-Based Self-Aggregates Bearing Iron Oxide Nanoparticles as a Multimodal Imaging Probe |
| 초록 |
In recent years, multimodal imaging techniques have received increasing attention because they allow early detection of inveterate diseases such as cancer, arthrosclerosis, and rheumatoid arthritis The aim of this study was to develop a potential multimodal imaging probe which can be selectively accumulated into the tumor tissue in vivo. The fluorescent dye, Cy 5.5, was chemically conjugated to the amphiphilic hyaluronic acid (HA) capable of being self-assembled into the nano-sized self-aggregates in an aqueous environments. The iron oxide nanoparticles were stably encapsulated within the Cy5.5-labeled hyaluronic acid-based nanoparticles. This encapsulation process did not disturb the magnetization properties of the encapsulated nanoparticles. The nanoparticles showed a potential as the multimodial imaging probe for optical and MR imaging techniques. |
| 저자 |
김아영1, 최기영1, 박재형1, 김광명2, 권익찬2
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| 소속 |
1경희대, 2한국과학기술(연) |
| 키워드 |
Iron oxide nanoparticle; MR; Hyaluronic acid
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| E-Mail |
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