| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Peroxisome-targeted supramolecular nanoprobes assembled with pyrene-labelled peptide amphiphiles |
| 초록 |
Despite the key metabolic functions of peroxisomes such as lipid synthesis and fatty acid oxidation and their relevance to genetically inherited diseases and peroxisomal enzyme deficiency, the importance of peroxisome as a therapeutic target has been underestimated due to its misconceptions of ancillary or redundant functions. Here, we present supramolecular nanostructured probes based on the self-assembly of peptide amphiphiles (PAs) with peroxisome-targeting ability in cells. The PA was designed to include a peroxisome-targeting tripeptide terminating with carboxylate group and a fluorescent dye at C- and N-terminal, respectively. Resultantly, the presence of the SKL-appended carboxyl group, the extent of α-helical propensity of the peptide block, and the fibrillar morphology of nanoassemblies affected the targeting efficiency of the supramolecular nanoprobe. This work provides important insights in designing organelle-targeting nanoparticles for the next-generation nanomedicines. |
| 저자 |
김인혜1, 방우영1, 김수용1, 진선미1, 현주용2, 한은희2, 이은지3
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| 소속 |
1충남대, 2한국기초과학지원(연), 3광주과학기술원 |
| 키워드 |
self-assembly; peptide amphiphile; peroxisome targeting; supramolecular nanoprobe; TEM tomography
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| E-Mail |
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