| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_고분자 |
| 제목 |
A facile and green functionalization of single-walled carbon nanotubes by polyampholytic polymers for drug delivery application |
| 초록 |
A novel process for the green chemistry approach of drug nanocarriers using sustainable conditions, and chemical methods involving one-pot synthesis of polymers and surface modification of SWCNTs is reported. Firstly, the polyampholytic alternating polymers were prepared with functional monomers by using thiol-ene chemistry in sustainable conditions. Then, the obtained polymers were applied for a direct functionalization onto the surface of SWCNTs in aqueous media with ultrasonication support through Diels-Alder click reaction. The synthesized hybrid was characterized by TGA, FT-IR, UV-vis, Raman spectroscopy and TEM. These hybrids were used as drug-nanocarriers to improve the drug loading capacity up to 150%. Finally, the in-vitro drug release profiles showed that there was a burst release of DOX at pH 5.5 when compare with the lower release rate at pH 7.4 in the physiological condition. |
| 저자 |
Quoc Thang Phan, 박한솔, 박찬, 홍성수, 임권택
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| 소속 |
부경대 |
| 키워드 |
polyampholytes; single-walled carbon nanotubes; thiol-ene click reaction; Diel-Alder reaction; green chemistry. |
| E-Mail |
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