| 초록 |
In this research, a biosensor competent for dual cancer detection utilizing the fluorescent properties, and the electrochemical shift was prepared from manganese dioxide-integrated polymer dots (MnO2@PD). Initially, the PDs show strong fluorescence emission, which was quenching after the integration of MnO2. Due to essentially MnO2 having low electrical resistivity, conjugated MnO2 and PD further enhanced the conductivity. Moreover, the MnO2@PD biosensor demonstrated the sensitivity toward extracellular alkaline phosphoric acid (ALP) and 2-phospho-L-ascorbic acid (AAP) expressed in cancer cells, resulting in hydrolysis of AAP and decomposition of the MnO2. The reaction causes the recovery of PD fluorescence and alters the resistivity of biosensors. This electrochemical signal can be collected wirelessly, enabling cancer diagnosis using a smartphone. |
