| 초록 |
In the field of tissue engineering and regenerative medicine, functional 3D cell scaffolds have enormous opportunities that can be applied to construct in vitro or in vivo tissue models. However, it is challenging to manufacture a 3D artificial structure with implementing cell distribution patterns and complex shapes. For these reasons, 3D bioprinting technology that can print living cells with biomaterial inks (bioinks) is expected to overcome these problems by spatiotemporal control. Hydrogel-based extrusion-type bio inks are widely used for their controllable mechanical properties. However, traditional bioinks have limitation of cell viability and printing resolution by their post-crosslinking process or densely crosslinked structure of bulk hydrogel. In this research, we proposed novel multiple-cells-laden 3D bioprinting ink based on visible light-crosslinkable alginate microgels with excellent biocompatibility and cell proliferation as well as superior physical properties that can construct stable and high resolution 3D structures. |
