| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Design of polymeric micelles for highly enhanced transfection that reduces polyplex-mediated cellular oxidative Stress. |
| 초록 |
Recently, the potential toxicity of nanomaterials has received increasing attention, since materials in nano-scale dimensions often display substantially different properties compared to bulk materials with the same composition and may have unexpected adverse effects on tissues and cells. Various inorganic or organic nanoparticles with diameters of a few hundred nanometers have been reported to cause inflammatory responses, oxidative injury, cellular cytotoxicity, or genotoxicity. A major pathway responsible for these adverse effects is thought to relate oxidative stress, which is often the result of excess intracellular reactive oxygen species (ROS). In this study, we formulated an antioxidative transfection system minimizing cellular oxidative stress for enhanced transfection. |
| 저자 |
김병덕, 김다훤, 임수연, LYUSIYAN, 박채은, 황위보, 정지훈
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| 소속 |
성균관대 |
| 키워드 |
Nonviral gene delivery; Polyplex; Nano; Antioxidative transfection system; Oxidative stress
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| E-Mail |
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