| 초록 |
Development of biodegradable nanoparticles(NPs)has gained attention because they can increase the bioavailability of anticancer drugs with low-toxicity.Chitosan(CS) is a chitin-derived natural polymer with high biocompatibility.So thus, CS has been widely used as safe and effective drug delivery carriers.Piperlongumine(PL) has the ability to trigger apoptosis through the increase of oxidative stress in a cell. Since oxidative stress in cancer cells is more prone to triggering apoptosis, PL can kill cancer cells more selectively than normal cells. However, PL is difficult to use in the clinic due to hydrophobic. In this study, CS was used to efficiently encapsulate PL by forming NPs through ionic gelation.CS NPs significantly increased water solubility and bioavailability of PL via ionic gelation.PL-CSNPs can induce pH-dependent drug release due to pH-sensitive of CS.The PL-CSNPs efficiently killed human gastric cancer cells via apoptosis through a dramatic increase in intracellular ROS |
