| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
고분자합성 |
| 제목 |
DOX/IR780 dye co-loaded polymeric vesicles as dual stimuli-responsive nanocarriers for synergistic chemo/photothermal therapy |
| 초록 |
Stimuli-responsive polymer nanocarriers mediated drug delivery is one of the most promising platforms for targeting antitumor treatment. In this work, by using a combination of reversible addition fragmentation chain transfer polymerization (RAFT) and ring opening polymerization, we present an efficient approach for preparing a series of disulfide-containing amphiphilic polypeptide hybrids, poly(N-isopropylacrylamide)-block-poly(3,4-dihydroxy-L-phenylalanine) (PNIPAM-b-PDOPA). After the aminolysis of the RAFT end group and the deprotection of acetyl group, the resulting hybrids were able to self-assemble into stabilized and uniform micelles in which doxorubicin and IR780 are efficiently encapsulated. The in vitro cell viability assays results illustrated that the PNIPAM-b-PDOPA hybrid bioconjugates might serve as highly biocompatible and multifunctional nanocarriers for practical applications. |
| 저자 |
yu zhang1, 김일1, Saji Uthaman2, 박인규2
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| 소속 |
1부산대, 2전남대 |
| 키워드 |
Chemotherapy; Drug delivery; Photothermal therapy
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| E-Mail |
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