| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Poly(PEGA)-b-poly(L-Lysine)-b-poly(L-histidine)Hybrid Vesicles for Tumoral pH-triggered Intracellular Delivery of Doxorubicin Hydrochloride |
| 초록 |
A series of poly(ethylene glycol) methyl ether acrylate-block-poly(L-lysine)-block-poly(L-histidine) [p(PEGA)30-b-p(Lys)25-b-p(His)n] triblock copolypeptides were designed and synthesized for tumoral pH-responsive intracellular release of anticancer drug doxorubicin hydrochloride (Dox). The tumoral acidic pH responsive hybrid vesicles fabricated were stable at physiological pH 7.4 and could gradually destabilize in acidic pH as a result of pH induced swelling of the p(His) block.The tumor acidic pH responsiveness of these vesicles was exploited for intracellular delivery of Dox. Vesicles efficiently encapsulated Dox, and pH-induced destabilization resulted in the controlled and sustained release of Dox in CT26 murine cancer cells, and dose-dependent cytotoxicity. The tumor specific controlled release Dox from vesicles demonstrates this system represents a promising theranostic agent for tumor-targeted delivery |
| 저자 |
Cherukula Kondareddy1, Saji Uthaman2, Renjith P.Johnson1, Santhosh Kalash2, Kamali Manickavasagam Lekshmi3, Il Kim4, 박인규5
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| 소속 |
1Department of Biomedical Science and BK 21 PLUS Center for Creative Biomedical Scientists, 2Chonnam National Univ. Medical School, 3160 Baekseo-ro, 4Gwangju, 5501-746 |
| 키워드 |
biocompatible polymer; self-assembly; nanovesicles; pH-responsive; anticancer drug delivery
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| E-Mail |
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