| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Doxycycline eluting core-shell nanofiber trachea stent for prevention of inflammation-induced fibrotic tissue formation |
| 초록 |
In this study, we investigated doxycycline-eluting nanofiber-covered endotracheal stent. Core-shell nanofiber was fabricated with co-axial electrospun system. Poly (DL-lactide) and polyurethane were, respectively, selected for shell and core forming materials. For the study, monolithic nanofiber and core-shell nanofiber with different core-shell thickness ratios were fabricated. SEM and TEM image proved well-structured core-shell nanofiber. Core-shell thickness was adjustable with changing the coaxial flow rates. We also studied the fluorescence materials loaded nanofibers characterized with microscopic analysis to distinguish with core-shell morphology. Core-shell nanofiber membrane showed the controlled release of doxycycline. Meanwhile single nanofiber showed the burst and maximum release within the short time. Further in vivo rabbit trachea implantation study, doxycycline-eluting nanofibers stent successfully inhibited a fibro vascular formation surrounding trachea tissue. |
| 저자 |
박지은1, 양수근1, Rengarajan Baskaran2, 경정수1
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| 소속 |
1인하대, 2인하대병원 |
| 키워드 |
Electrospinning; Coaxial nanofiber; In vitro drug release; Doxycycline; Trachea stent
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| E-Mail |
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