| 초록 |
DNA has been extensively studied in the context of self-assembled nanostructures. Due to the specificity of DNA hybridization and programmability of the sequences, it is possible to create intricate and beautiful DNA structures on the nanoscale. This talk will mostly focus on DNA hybrid materials, DNA amphiphiles that have synthetic hydrophobic segments covalently connected to oligodeoxyribonucleotides. These materials exhibit both the self-recognition properties of DNA and the aggregation behavior of amphiphilic molecules. Among such self-assembled aggregates, micelles are templating the formation of virus-like particles, delivering pharmaceutical compounds to cornea, and stimulating dendritic cells. This delivery strategy proved the potency of the DNA amphiphiles for advanced therapeutics in vivo. |
