| 초록 |
Liposomes have been widely used for target encapsulation and delivery due to their self-assembly capability and high biocompatibility. Depending on the surface chemistry of the targets, the formed liposomes may exhibit monolayer or bilayer morphologies. One major drawback of the system, however, is its lack of target specificity. In this work, we mark the target polystyrene (PS) beads with DNA, then hybridize the marked targets with DNA-lipid block copolymers containing complementary DNA. The lipid blocks on the outer surface of the PS beads can recruit free lipid molecules to form liposomes surrounding the PS beads, thus achieving target specific encapsulation. We also show that the encapsulation behavior can be influenced by the nature of the capping molecules. A number of different capping agents including poly(ethylene glycol) and dodecane were used, and their interaction with lipid molecules and liposome formation are examined. |
