| 초록 |
Alginate hydrogels can be easily formulated to carry drugs and/or cells by simple mixing followed by a chemical or physical curing process. Injectable alginate hydrogels offer a wide range of attractive benefits, as an easy-to-use medical device for various applications. In this work, injectable hydrogels were fabricated by modification of alginate with tyramine and subsequent enzyme-catalyzed reaction. The modified alginate was analyzed by ATR-FTIR, 1H-NMR in order to confirm the introduction of tyramine. Rheological properties were also tested according to adjust the amount of H2O2, HRP and concentration of modified alginate solutions. As a result, the hydrogels were successfully synthesized. The results for gelation time and mechanical strength revealed that both the rate and degree of cross-linking in hydrogels were fairly well controlled by changing the H2O2 and HRP concentrations. In addition, the degradation rates were controllable by adjusting the degree of cross-linking. |
