| 초록 |
Implantable drug delivery systems for the sustained drug delivery provide advantages such as improved bioavailability of drugs and reduced side effects. However, the devices are mostly made of hard materials that may need large incision size and cause discomfort after implantation. To resolve these, we developed an implantable device made of a soft polymer, polydimethylsiloxane. For controlled drug delivery, gelatin hydrogel was filled to serve as a drug diffusion barrier. By varying the lengths of channels, we precisely controlled a drug release onset time and rate, which were modulated from day 1 to day 14 and from 0.4 %/day to 4.3 %/day, respectively. Given those, we prepared a device integrated with multiple pairs of channels and reservoirs, exhibiting almost zero-order release for 55 days. In pharmacokinetics study, the average drug concentrations in the blood were maintained within a narrow range of 44-103 ng/ml due to the reproducible release of drug even after device folding. |
