| 초록 |
Microfluidic devices have been conducted in many chemical and biological applications. We developed polymeric nanoporous membrane-embedded microfluidic system where the membrane fulfilled anti-fouling ability and chemical functionality as well as physical strength. This system helps delivering materials throughout microfluidic channel effectively to perform for selective reaction and detection from the sample solution. In order to generate spontaneous flow of the analytic solution within the micro channel, we utilized layer-by-layer deposition method to modify the inner surface of the device. Also, we formed micro-contact printing with peptide containing RGD on deposited film for selective biomolecule patterning. Cell adhesion and proliferation in the modified microfluidic device exhibited excellent biocompatibility, and the membrane performed moderately good separation property. Using this microfluidic system, it is possible to detect biomolecules with more reliable detection signal. |
