| 초록 |
Epitope is portion of protein or antigen as the antigenic determinant. The introduction of epitope allows for potentially many applications in the bio-field, such as drug delivery and cell growth. We use the molecularly imprinted polymer (MIP) system as a tool for epitope recognition. The MIP system enables selective recognition of template by making recognition sites. MIP system is being studied in various fields, among them, micro/nano-scale surface patterning research is actively carried out to improve the imprinting ability. In this regard, we propose epitope-imprinted polymer (EIP) with a multilayer opal structure. EIP made of 2-hydroxyethyl acrylamide, methylene bisacrylamide, 4-acrylamidophenyl(amino)methaniminium chloride and 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone as backbone, cross-linker, monomer and photo initiator, respectively. EIP can be grown by attaching specific cell and it will contribute to the development in the fields of cell biology and diagnostics. |
