| 학회 | 한국화학공학회 |
| 학술대회 | 2014년 가을 (10/22 ~ 10/24, 대전 DCC) |
| 권호 | 20권 2호, p.1499 |
| 발표분야 | 분리기술 |
| 제목 | A quantitative approach to monitoring antisolvent crystallization of clopidogrel hydrogen sulphate by Raman spectroscopy |
| 초록 | Polymorphism is the ability of a compound to crystallize as more than one distinct crystal species. Properties of APIs such as bioavailability, compressibility, dissolution, stability and shelf life are affected by form of the polymorph. In this study, quantification of form I and form II of clopidogrel hydrogen sulphate (CHS) was monitored. Antisolvent crystallization of CHS was carried in a methanol-isopropanol mixture while been monitored by Raman spectroscopy in-line. Experiments were conducted at 25 oC using an antisolvent fraction of 0.7 to 0.85. The induction times of form I and II were easily deduced which is critical to the kinetics of the system. Validated partial least squares method was successfully used in the quantification of form II in the polymorph mixture. |
| 저자 | Ernest Ansah Owusu, 김광주 |
| 소속 | 한밭대 |
| 키워드 | Clopidogrel hydrogen sulfate; Raman spectroscopy; polymorphic transformation; antisolvent crystallization |
| 원문파일 | 초록 보기 |
