| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Preparation and anticancer effect of pegylated-chlorambucil prodrug nanoparticle on the based on drug delivery system |
| 초록 |
Chlorambucil (CLB), used as therapeutic agent for leukemia, was recently demonstrated to anticancer effect against various cancer cells. However, its utilization has been limited due to MDR effect, high toxicity and low solubility against water. To overcome these obstacles, we synthesized pegylated-CLB by using coupling agents. Their chemical structure was analyzed by 1H-NMR and UV-vis spectrophotometer. To demonstrate a dispersity of them against water, transmittance was measured by using UV-vis spectrophotometer. Their particle size and morphology were analyzed by DLS and TEM. Moreover, cytotoxicity and anticancer effect were evaluated by using MTT assay. In addition, their cellular uptake against cancer cell lines was observed by using fluorescence microscopy and flow cytometry. These results suggest that they can use as anticancer agent. (NRF-2016H1D5A1910499). |
| 저자 |
정은희, 정경원, 홍웅길, 안준혁, 김준수, 이승재, 심왕근, 나재운
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| 소속 |
순천대 |
| 키워드 |
Chlorambucil; Pegylated-chlorambucil; Prodrug; Nanoparticle; Anticancer effect
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| E-Mail |
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