| 초록 |
We synthesized the poly(2-hydroxyethyl asparamide)-graft-Oligo(cysteine)(PHEA-g-OC) amphiphilic graft copolymers which is the synthetic peptide. Because the oligo(cysteine) is hydrophobic, the PHEA-g-OC formed veslicle like aggregates in aqueous solution by precipitation-dialysis method. The size and bilayer thickness of vesicle were controlled by varying the length of oligo(cysteine) and degree of substitution. Thiol residues of oligo(cysteine) were easily cross-linked by oxidation reaction and formed disulfide linkages. The hydrophilic anti-cancer drug, DOXHCl, was encapsulated in aqueous cavity of cross-linked PHEA-g-OC vesicle. The release of DOXHCl was facilitated in a reductive environment. |
